Major hedge funds overhaul portfolios in Q1 2026 with bold tech and biotech bets
Major investment firms have reshuffled their portfolios during the first quarter of 2026. Duquesne Family Office made sweeping changes, exiting several long-standing positions while building new stakes in technology and biotech. Meanwhile, TCI Fund Management adjusted its holdings in tech giants, and Third Point entered fresh markets with bets on social media, cryptocurrency, and gold. Duquesne Family Office cut ties with multiple companies in Q1 2026. The firm sold off its entire 385,000-share stake in Alphabet (GOOGL), despite the stock rising 27% year-to-date by Friday’s close. It also exited positions in State Street Financial Select Sector SPDR, Cogent Biosciences, Entegris, Delta Air Lines, and American Airlines.
The firm then redirected capital into new investments. A significant stake of 1.89 million shares was established in Caris Life Sciences, alongside a 195,955-share position in Broadcom. Additionally, Duquesne took a new holding in Revolution Medicines while slashing its Amazon holdings from 737,940 shares to just 9,539. Elsewhere, TCI Fund Management made bold moves in Microsoft and Alphabet. The firm drastically reduced its Microsoft stake from 16.78 million shares to 2.73 million. At the same time, it built a fresh 2.46 million-share position in Alphabet Class A and expanded its Class C holdings to 8.85 million shares. Third Point also diversified its portfolio with new entries. The fund initiated positions in Meta, Alphabet, bitcoin miner Hut 8, and the SPDR Gold Shares ETF.
The first quarter of 2026 saw Duquesne Family Office exit multiple sectors while doubling down on biotech and tech. TCI Fund Management shifted its focus within the tech industry, and Third Point spread its investments across digital assets, precious metals, and major platforms. These adjustments reflect broader trends in institutional portfolio strategies for the year ahead.
